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Abstract


INTERNATIONAL DENTAL JOURNAL OF STUDENTS RESEARCH - VOLUME 1 ISSUE 3, Oct-Jan 2013

Pages: 24-35

MESENCHYMAL STEM CELL-BASED BONE TISSUE ENGINEERING

Author: Mohammad A. Javaid, Mari T. Kaartinen

Category: Review Article

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Abstract:

Every year more than 2.2 million people worldwide undergo bone grafting due to critical sized bone defects arising from trauma, disease, tumor resection and accidents. These large bone defects that do not heal by themselves are still a challenge to reconstructive surgery and many approaches are being used to replace the lost bone. The newest methods involve the use of patient’s own mesenchymal stem cells which are incorporated into the biomaterials that are shaped and modelled to the contours of the defect. These grafts can incite and promote natural healing and replacement of bone without inducing immune responses  and rejection of the graft. Mesenchymal stem cells have the potential to develop into bone forming cells under appropriate conditions and since they can be isolated from many adult tissues, they can be ideal for tissue regeneration. In this review we discuss current materials and use of mesenchymal stem cells for development of tissue engineered bone constructs. Many promising results have been obtained both, in vitro and in vivo from animal experiments as well as from clinical studies.  

Assembly of this article was supported by grant from Canadian Institutes of Health Research (CIHR) to Mari T. Kaartinen.

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