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Abstract


INTERNATIONAL DENTAL JOURNAL OF STUDENTS RESEARCH - VOLUME 1 ISSUE 2, June-Sept 2012

Pages: 48-55

ENDOTHELIAL CELL BASED ENGINEERING OF CAPILLARIES-LIKE NETWORK IN A TISSUE-ENGINEERED SKIN SUBSTITUTE

Author: Dr. Mohammad Ahmad Javaid

Category: Review Article

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Abstract:

Treatment of patients with burns, surgeries and accidents involving extensive skin replacement has long been a challenge for reconstructive surgery. Classical approaches like cadaver skin or xenografts have failed to provide a permanent solution to this ever increasing problem. Different tissue engineering techniques have been tried in the past but, clinically none has lived up to the early promise that in vitro studies showed mostly, due to limited vascular supply leading to cell death when grafts comprising of epidermis and dermis were used in deep wounds.  More recently scientists have developed a new approach using endothelial cells for construction of pre vascularised tissue engineered skin grafts constituting epidermis and dermis. In this mini review we look at a few experiments and animal studies which have been conducted so far and have yielded promising results, both in vitro and in vivo. This new approach involving endothelial cells for engineering of capillary like network in tissue engineered skin substitute is the way forward and can potentially provide a solution to this problem which scientists and surgeons have been trying to address for the last half century.

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