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Abstract


INTERNATIONAL DENTAL JOURNAL OF STUDENTS RESEARCH - VOLUME 2 ISSUE 3, October 2014

Pages: 08-16

DETERMINATION OF BISGMA BY ETHANOL RELEASE FROM DENTAL COMPOSITES

 

Author: PhD Ignacio Moreno-Villoslada3, Nicolas Cohn-Inostroza1 Camila De la Rosa-Varela2

Category: Original Research

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Abstract:

Photopolymerized dental composite resins are periodically used in the field of dentistry, but the rate of polymerization ranges from 55% to 75%. Therefore BisGMA the unreacted monomers in the polymer network reduces clinical longevity of these resins. These substances can penetrate the dentin, may irritate soft tissue and promote allergic reactions. It has been found that the release of these substances have cytotoxic, genotoxic, mutagenic and estrogenic effects.

Objectives: The developmentof an analytical method for detection of BisGMA, using molecular absorption spectrophotometry UV-vis and high performance liquid chromatography (HPLC) in ethanol and acetonitrile, and study the BisGMA solubility using HPLC at different ethanol concentrations.

Methods: Three coins of dental composite (3 mm diameter and 1.5 mm thick) are immersed in 1.5 ml of ethanol 12% vol/vol, 35% vol/voland 50% vol/vol, stored in an Eppendorf tube. Emulating alcohol intake. After 1 and 22 days, removed composites and proceeds to measure the solutions in HPLC.

Results: HPLC obtained concentrations between 1.15 E-7 [M] and 4.84 E-4 [M] of BisGMA from a dental composite resin.

Conclusions: The release of BisGMA from the organic matrix of dental composite resin is alcoholic dependent. The release of BisGMA concentrations in the alcoholic described except 12% vol/vol, saturate the β- estrogen receptor, which according to the literature cause an exoestrogenic effect.

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