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Abstract


INTERNATIONAL DENTAL JOURNAL OF STUDENTS RESEARCH - VOLUME 2 ISSUE 3, October 2014

Pages: 17-24

ALTERATIONS IN SERUM LIPID PROFILE PATTERNS IN HEAD & NECK CANCER AND ORAL SUBMUCOUS FIBROSIS PATIENTS

Author: Dr. Nupur Gupta1 Dr. Ravi Prakash Sasankoti Mohan2 Dr. Sankalp Verma 3 Dr. Soumi Ghanta4 Dr. Neha Agarwal5 Dr. Navin Sankar6

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Abstract:

Background: The changes in lipid profile have long been associated with cancer because lipids play a key role in maintenance of cell integrity. The present study evaluated alterations in serum lipid profile patterns in head & neck cancer & oral submucous fibrosis patients as well as the changes seen in their different stages.

Materials & methods: A total of 95 subjects who were clinically diagnosed as patients of head & neck cancer and oral submucous fibrosis & age and sex matched healthy controls were studied in the outpatient department of Kothiwal Dental College & Research Centre, Moradabad from October 2011 to November 2012. The lipid profile values including (i) serum cholesterol (ii) low density lipoprotein cholesterol (iii) high density lipoprotein cholesterol (iv) very low density lipoprotein cholesterol (v) serum triglyceride were estimated. Also the lipid profile values in TNM (primary tumor, regional lymph node, distant metastasis) staging in head & neck cancer patients & functional staging of oral submucous fibrosis patients were also estimated. These values were subjected for statistical analysis.

Results: Mean lipid levels were found to be maximum in oral cancer patients for all the parameters except serum high density lipoprotein cholesterol. For all the variables except serum low density lipoprotein cholesterol, minimum values were observed in oral submucous fibrosis patients. For serum low density lipoprotein cholesterol minimum values were observed in control group.

Conclusion: Our study found a direct relationship between lipid profile & cancer patients & an inverse relationship between lipid profile & oral submucous fibrosis patients. The findings strongly warrant an in depth study of alterations in serum lipid profile patterns in head & neck cancer & oral submucous fibrosis patients.

Keywords: Serum cholesterol, serum triglyceride, high density lipoprotein, low density lipoprotein, very low density lipoprotein, oral submucous fibrosis.

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